Testosterone shows promise for treating endometrial cancer: a study


Sydney, August 27: A study showed that testosterone may play an important role in the development of endometrial cancer.

The discovery, made by the QIMR Berghofer Institute for Medical Research in Australia, raises exciting new possibilities for screening, prevention and control of this increasingly prevalent disease.

Cancer treatment options are limited, and hysterectomy is often the first line of defense.

Associate Professor Tracy O’Mara, from the institute, said: “Everyone has testosterone, but our research suggests that women who have higher levels of the hormone are more likely to develop endometrial cancer.”

“By establishing an independent relationship between testosterone and endometrial cancer, the study opens up new potential avenues for treatment.

“We’re really excited about these results and hope that with more research, we may be able to treat endometrial cancer by targeting or blocking testosterone with existing drugs,” O’Mara said.

In the study, published in the journal iScience, researchers conducted an advanced genetic analysis to identify five independent risk factors for endometrial cancer.

These risk factors include body weight, age at onset of menstruation and menopause, and testosterone levels. Testosterone was associated with a specific region of the human genome, which the study found to be associated with an increased risk of endometrial cancer.

“It’s very promising to see testosterone levels emerge so strongly as a potential risk factor, because a person’s testosterone can be modulated,” O’Mara said.

“There are already approved medications designed to prevent and counteract the effects of the hormone. More research may justify trying to repurpose these drugs to help women with endometrial cancer.” It’s really important that we find more treatment options, such as the current first-line treatment for endometrial cancer which is hysterectomy. . This is clearly a very invasive procedure, affecting fertility in younger patients.”

According to Dylan Globe, an associate professor from QIMR, they said they would use lab-grown organoids that resemble endometrial cancer tumors, to investigate the genes involved in the development of the disease.

“We have identified a large number of genetic regions associated with endometrial cancer, but we do not yet know which specific genes are responsible. This study allows us to test genes important for the growth of organelles and the endometrial cancer tumors that cause them.” Represent.

“Our ultimate goal is to find new genes that can be targeted to treat endometrial cancer, because we know that drugs with a genetic basis are more likely to be effective.”



Source: IANS

Disclaimer: This story has not been edited by the WBSETCL team and is auto-generated from syndicated feed.

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